Kalsarya, Reema A., Kavila, Dave, Shorter, Susan, Negi, Deepika, Goodall, Iain C.A., Boussios, Stergios and Ovsepian, Saak V. (2025) Molecular biomarkers of glial activation and injury in epilepsy. Drug Discovery Today, 30 (2):104289. pp. 1-10. ISSN 1359-6446 (Print), 1878-5832 (Online) (doi:10.1016/j.drudis.2025.104289)

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Abstract

Increasing evidence from fluid biopsies suggests activation and injury of glial cells in epilepsy. The prevalence of clinical and subclinical seizures in neurodegenerative conditions such as Alzheimer’s disease, frontotemporal dementia and others merits review and comparison of the effects of seizures on glial markers in epilepsy and neurodegenerative diseases with concomitant seizures. Herein, we revisit preclinical and clinical reports of alterations in glial proteins in cerebrospinal fluid and blood associated with various types of epilepsy. We consider shared and distinct characteristics of changes in different age groups and sexes of humans and animal models of epilepsy and compare with those reported in biofluids of neurodegenerative diseases. Our analysis indicates a significant overlap of glial response in these prevalent neurological conditions.

Item Type:	Article
Uncontrolled Keywords:	neurodegeneration, GFAP, S100β, IL-1β, IL-6, TNF-α, HMGB1, fluid biopsy, status epilepticus, neuroinflammation
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	04 Mar 2025 15:27
URI:	http://gala.gre.ac.uk/id/eprint/49933

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