Brako, Francis and Boateng, Joshua ORCID: https://orcid.org/0000-0002-6310-729X (2025) Transmucosal drug delivery: prospects, challenges, advances, and future directions. Expert Opinion on Drug Delivery. ISSN 1742-5247 (Print), 1744-7593 (Online) (In Press)

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Abstract

Introduction: Traditional administration routes have limitations including first-pass metabolism and gastrointestinal degradation for sensitive drugs (oral)and pain associated with parenteral injections which also require trained personnel and n refrigeration, making them expensive. This has increased interest in alternative routes, with mucosal surfaces being of high priority.
Areas covered: Mucosal routes include ocular, oral (buccal,/ sublingual), nasal and vaginal mucosa which avoid the limitations of the oral and parenteral routes. Though mucosal routes show great potential, they are still hindered by several barriers, especially for systemic absorption, resulting in the development of more advanced novel drug delivery systems to overcome these limitations to achieve therapeutic actions both locally and systemically, similar to or exceeding the oral route. This review systematically reviews and compares the different mucosal routes, challenges and recent advances in advanced novel drug delivery system design for emerging clinical challenges including the advent of large biological macromolecules (proteins, peptides and RNA) for treatment and prevention of diseases. The review also focuses on current challenges and future perspectives.

Item Type:	Article
Uncontrolled Keywords:	transmucosal drug delivery, buccal, sublingual, ocular, nasal, vaginal, mucoadhesion, mucosa
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	21 Feb 2025 09:12
URI:	http://gala.gre.ac.uk/id/eprint/49794

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