Protopapa, Chrystalla, Siamidi, Angeliki, Junqueira, Laura Andrade, Kolipaka, Siva, Tabriz, Atabak Ghanizadeh, Douroumis, Dennis ORCID: 0000-0002-3782-0091 and Vlachou, Marilena (2024) Sustained release of 3D printed bupropion hydrochloride tablets bearing Braille imprints for the visually impaired. International Journal of Pharmaceutics, 663:124594. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2024.124594)

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PDF (Open Access article) 48548 DOUROUMIS_Sustained_Release_Of_3D_Printed_Bupropion_Hydrochloride_Tablets_Bearing_Braille_imprints_For_The_Visually_Impaired_(OA)_2024.pdf - Published Version Available under License Creative Commons Attribution. Download (3MB) | Preview

Abstract

3D printing has been introduced as a novel approach for the design of personalized dosage forms and support patient groups with special needs that require additional assistance for enhanced medication adherence. In this study liquid crystal display (LCD) is introduced for the development of sustained release bupropion.HCl printed tablets. The optimization of printing hydrogel inks was combined with the display of Braille patterns on the tablet surface for blind or visually impaired patients. Due to the high printing accuracy, the Braille patterns could be verified by blind patients and provide the required information. Further characterization revealed the presence of BUP in amorphous state within the photopolymerized resins. The selection of poly(ethylene glycol) (PEG)-diacrylate (PEGDA) of different molecular weights and the presence of surfactants or solubilizers disrupted the resin photopolymerization, thus controlling the BUP dissolution rates. A small batch scale-up study demonstrated the capacity of LCD to print rapidly a notable number of tablets within 24 min.

Item Type:	Article
Uncontrolled Keywords:	3D printing, Liquid Crystal Display (LCD), braille imprint, personalized medicine, sustained release
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	06 Nov 2024 11:24
URI:	http://gala.gre.ac.uk/id/eprint/48548

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