Zhu, YuZhu, Wang, Dong, Zhou, Shaobo ORCID: 0000-0001-5214-2973 and Zhou, Tao (2024) Hypoglycemic effects of Gynura Divaricata (L.) DC Polysaccharide and action mechanisms via modulation of gut microbiota in diabetic mice. Journal of Agricultural and Food Chemistry. ISSN 0021-8561 (Print), 1520-5118 (Online) (doi:https://doi.org/10.1021/acs.jafc.4c00626)

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Abstract

Aiming to provide a basis for the application of Gynura divaricata (L.) DC polysaccharide (GDP) in functional foods, the hypoglycemic effects of GDP, and action mechanisms were investigated. Results showed that GDP effectively inhibited α-glucosidase and remarkably increased the glucose absorption, glycogen content, and pyruvate kinase and hexokinase activities of insulin resistant-HepG2 cells, indicating its potent in vitro hypoglycemic effect. In streptozotocin-induced type 2 diabetes mice, GDP significantly improved various glycolipid metabolism-related indices in serum and liver, e.g., fasting blood glucose, oral glucose tolerance, glycosylated serum protein content, serum insulin level, antioxidant enzyme activities, TG, TC, LDL-C, and HDL-C levels, hepatic glycogen content etc.; recovered the structure of gut microbiota to the normal level. It was also found that GDP significantly affected the expression of related genes in PI3K/Akt, AMPK, and GS/GSK-3β signaling pathways. Therefore, GDP regulates blood glucose possibly by directly inhibiting α-glucosidase, exerting antioxidant activity, and regulating intestinal microbiota.

Item Type:	Article
Uncontrolled Keywords:	Gynura divaricata (L.) DC polysaccharide; hypoglycemic effect; intestinal flora
Subjects:	Q Science > Q Science (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	24 Apr 2024 08:54
URI:	http://gala.gre.ac.uk/id/eprint/46824

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