Salinas, Y. ORCID: https://orcid.org/0000-0002-1828-5839, Castilla, Ana Maria ORCID: https://orcid.org/0000-0002-5895-6190 and Resmini, M. ORCID: https://orcid.org/0000-0001-8109-5352 (2018) An L-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle. Polymer Chemistry, 9 (17). pp. 2271-2280. ISSN 1759-9954 (Print), 1759-9962 (Online) (doi:10.1039/C8PY00308D)

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Abstract

The synthesis and characterisation of a novel dual stimuli-responsive nanogel, based on thermoresponsive N-n-propylacrylamide and an L-proline based monomer acting as a pH-switcher, is reported here. The effect of the crosslinker/co-monomer ratios was studied to demonstrate the relationship between the chemical structure, degree of hydrophobicity and physico-chemical characteristics of the nanogels. Tailoring of the thermoresponsive properties was achieved by altering crosslinker N,N′-methylenebis(acrylamide) content between 10 and 50 mol%, in combination with three thermoresponsive monomers N-n-isopropylacrylamide, N-n-propylacrylamide and N-acryloylpyrrolidine. A library of 25 different combinations of monomers and crosslinkers was obtained and characterised by dynamic light scattering and UV-Vis spectroscopy. The nanogel based on N-n-propylacrylamide and 10 mol% crosslinker was then co-polymerised with an L-proline based monomer to introduce a pH-switch. This nanogel was obtained with <10 nm particle size and a VPTT ca. 43 °C, and was used to demonstrate a drug delivery capability using Nile Blue A as a model drug. Detailed studies demonstrated maximum drug release at lower pH and 43 °C, thus confirming the dual stimuli switch.

Item Type:	Article
Uncontrolled Keywords:	drug delivery; nanotechnology; polymer chemistry; nanogels; nanoparticles
Subjects:	Q Science > Q Science (General) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	22 Jan 2024 14:38
URI:	http://gala.gre.ac.uk/id/eprint/45405

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