Ergen, Pinar Helin, Shorter, Susan, Ntizachristos, Vasilis and Ovsepian, Saak (2023) Neurotoxin-derived optical probes for biological and medical imaging. Molecular Imaging and Biology, 25. pp. 799-814. ISSN 1536-1632 (Print), 1860-2002 (Online) (doi:10.1007/s11307-023-01838-1)

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Abstract

The superb specificity and potency of biological toxins targeting ion channels and receptors are of major interest for delivering therapeutics to distinct cell types and subcellular compartments. Fused with reporter proteins or labelled with fluorophores and nanocomposites, animal toxins and their detoxified variants also offer expanding opportunities for visualization of a range of molecular processes and functions in preclinical models, as well as clinical studies. This article presents state-of-the-art optical probes derived from neurotoxins targeting ion channels, with discussions of their applications in basic and translational biomedical research. It describes the details of the design and production of probes and reviews their applications with advantages and limitations, with prospects for future improvements. Given the advances in imaging tools and expanding research areas benefiting from the use of optical probes, the resources described here should assist the discovery process and facilitate high-precision research and therapeutic interventions.

Item Type:	Article
Uncontrolled Keywords:	advanced biomaterials; animal toxins; fluorescent probes; ICG; Ion channels; optical imaging; visualisation
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	15 Jan 2024 13:16
URI:	http://gala.gre.ac.uk/id/eprint/45352

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