Xue, Xiangdong, Bailey, Chris ORCID: https://orcid.org/0000-0002-9438-3879 and Patel, Mayur K. (2010) Design modification of a biochip microchannel separator with integrated curve constrictions for enhanced separation behaviour. In: Proceedings - 2010 11th International Conference on Electronic Packaging Technology and High Density Packaging, ICEPT-HDP 2010. Association for Computing Machinery, New York, pp. 691-697. ISBN 9781424481408 (doi:10.1109/ICEPT.2010.5582861)

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Abstract

This paper reports a design modification of a biochip microchannel plasma blood separator. Among the three geometric characteristics, i.e. bifurcation, constriction and bending channel, which have been widely used in promoting biofluid separation, the original separator (Figure 1) has put the focus on the bifurcation effect and also adopts a constriction at the inlet end to implement some constriction effect. This modification is targeted to a strong integrative application of these three channel geometries characteristics. For this purpose, curve/arc constrictions are implemented inside the bifurcation region between bifurcations, so that both constriction and bending channel effects can be effectively fulfilled at each bifurcation to increase the effectiveness. Both 2D and 3D designs for fulfilling this modification are offered. The flow field and separation process in the modified 2D biochip are analyzed using computational fluid dynamics (CFD) technique and compared with the original separator. Comparably the modified design leads to more volumetric separation of plasma rich fluid from the side channels and results in low flow rate ratio due to the increased channel resistance in the main channel. Improvements in using constriction and bending channel effects have been numerically evidenced.

Item Type:	Conference Proceedings
Title of Proceedings:	Proceedings - 2010 11th International Conference on Electronic Packaging Technology and High Density Packaging, ICEPT-HDP 2010
Additional Information:	This paper forms part of the published proceedings from 2010 11th International Conference on Electronic Packaging Technology and High Density Packaging, ICEPT-HDP 2010 August 16, 2010 - August 19, 2010 Xi'an, China
Uncontrolled Keywords:	biofluid separation, bifurcation effect, constriction effect
Subjects:	Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Pre-2014 Departments:	School of Computing & Mathematical Sciences School of Computing & Mathematical Sciences > Department of Computer Systems Technology School of Computing & Mathematical Sciences > Department of Mathematical Sciences
Related URLs:	Publisher Organisation Organisation Organisation
Last Modified:	13 Mar 2019 11:33
URI:	http://gala.gre.ac.uk/id/eprint/4507

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