Ovsepian, Saak and O'Leary, Valerie (2022) Adult neurogenesis in the gut, homeostatic autoimmunity and neurodegenerative disease biomarkers. Neuroscience, 10 (504). pp. 75-78. ISSN 0306-4522 (doi:10.1016/j.neuroscience.2022.09.019)

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Abstract

Autoantibodies to neuronal antigens are viewed as potential biomarkers for neurodegenerative diseases. Increasing evidence, however, suggests a dissociation of the neurodegenerative process in the central nervous system and dynamics of neuronal proteins in peripheral circulation with the prevalence of a wide variety of immunoglobulins reactive to neuronal antigens also reported in the blood of healthy subjects, including children. Recently discovered physiological turnover of neurons in the enteric nervous system with the release of neuronal proteins in circulation may account for this puzzle and provide a new perspective on molecular biomarkers of neurodegenerative diseases and immunotherapy.

Item Type:	Article
Uncontrolled Keywords:	adult neurogenesis; autoimmunity; biomarkers; enteric nervous system; neurodegenerative disease; tau
Subjects:	Q Science > Q Science (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Biomedical Science Research Group Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	11 Nov 2023 01:38
URI:	http://gala.gre.ac.uk/id/eprint/38215

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