Clout, Alexander E., Buanz, Asma B. M. ORCID: 0000-0002-2556-1256 , Gaisford, Simon and Williams, Gareth R. (2018) Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine. Chemistry A European Journal, 24 (51). pp. 13573-13581. ISSN 0947-6539 (Print), 1521-3765 (Online) (doi:https://doi.org/10.1002/chem.201802368)

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Abstract

Temperature-induced phase transitions in carbamazepine (CBZ) and 10,11-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry–X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localised melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, again by a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I.

Item Type:	Article
Uncontrolled Keywords:	hyphenated techniques, pharmaceutical materials, phase transitions, synchrotron X-ray diffraction, thermal analysis
Subjects:	Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	24 Aug 2022 15:37
URI:	http://gala.gre.ac.uk/id/eprint/37192

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