Lapthorn, Cris and Pullen, Frank (2009) 'Soft or 'hard' ionisation? Investigation of metastable gas temperature effect on direct analysis in real time of Voriconazole. European Journal of Mass Spectrometry, 15 (5). pp. 587-593. ISSN 1469-0667 (Print), 1356-1049 (Online) (doi:https://doi.org/10.1255/ejms.1022)

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Abstract

The performance of the direct analysis in real-time (DART) technique was evaluated across a range of metastable gas temperatures for a pharmaceutical compound, Voriconazole, in order to investigate the effect of metastable gas temperature on molecular ion intensity and fragmentation. The DART source has been used to analyse a range of analytes and from a range of matrices including drugs in solid tablet form and preparations, active ingredients in ointment, naturally occurring plant alkaloids, flavours and fragrances, from thin layer chromatography (TLC) plates, melting point tubes and biological matrices including hair, urine and blood. The advantages of this technique include rapid analysis time (as little as 5 s), a reduction in sample preparation requirements, elimination of mobile phase requirement and analysis of samples not typically amenable to atmospheric pressure ionisation (API) techniques. This technology has therefore been proposed as an everyday tool for identification of components in crude organic reaction mixtures

Item Type:	Article
Uncontrolled Keywords:	DART, ionisation, energy, voriconazole, metastable, helium, ambient
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	27 Jan 2020 12:27
URI:	http://gala.gre.ac.uk/id/eprint/3633

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