Silver, Matt J., Corbin, Karen D., Hellenthal, Garrett, da Costa, Kerry-Ann, Dominguez Salas, Paula ORCID: 0000-0001-8753-4221 , Moore, Sophie E., Owen, Jennifer, Prentice, Andrew M., Hennig, Branwen J. and Zeisel, Steven H. (2015) Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. FASEB Journal, 29 (8). pp. 3426-3435. ISSN 0892-6638 (Print), 1530-6860 (Online) (doi:https://doi.org/10.1096/fj.15-271056)

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Abstract

Choline is an essential nutrient, and the amount needed in the diet is modulated by several factors. Given geographical differences in dietary choline intake and disparate frequencies of single-nucleotide polymorphisms (SNPs) in choline metabolism genes between ethnic groups, we tested the hypothesis that 3 SNPs that increase dependence on dietary choline would be under negative selection pressure in settings where choline intake is low: choline dehydrogenase (CHDH) rs12676, methylenetetrahydrofolate reductase 1 (MTHFD1) rs2236225, and phosphatidylethanolamine-N-methyltransferase (PEMT) rs12325817. Evidence of negative selection was assessed in 2 populations: one in The Gambia, West Africa, where there is historic evidence of a choline-poor diet, and the other in the United States, with a comparatively choline-rich diet. We used 2 independent methods, and confirmation of our hypothesis was sought via a comparison with SNP data from the Maasai, an East African population with a genetic background similar to that of Gambians but with a traditional diet that is higher in choline. Our results show that frequencies of SNPs known to increase dependence on dietary choline are significantly reduced in the low-choline setting of The Gambia. Our findings suggest that adequate intake levels of choline may have to be reevaluated in different ethnic groups and highlight a possible approach for identifying novel functional SNPs under the influence of dietary selective pressure.

Item Type:	Article
Uncontrolled Keywords:	gambia, nutrition, epigenetics
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics S Agriculture > S Agriculture (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > FaNSI - Food Systems for Improved Nutrition
Related URLs:	http://www.ncbi.nlm.nih.gov/pmc/articles... http://pubmed.ncbi.nlm.nih.gov/25921832/
Last Modified:	09 Sep 2021 08:31
URI:	http://gala.gre.ac.uk/id/eprint/33788

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