Sarheed, Omar, Shouqair, Douha, Ramesh, KVRNS, Amin, Muhammad, Boateng, Joshua ORCID: 0000-0002-6310-729X and Drechsler, Markus (2020) Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery. Therapeutic Delivery, 11 (11). pp. 685-700. ISSN 2041-5990 (Print), 2041-6008 (Online) (doi:https://doi.org/10.4155/tde-2020-0075)

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Abstract

Aim:
To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process.

Results/methodology:
Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine.

Conclusion:
Stable SLNs were successfully prepared by ultrasound-assisted PIT.

Item Type:	Article
Uncontrolled Keywords:	Franz diffusion cell; permeation; phase inversion temperature; pig skin; solid lipid nanoparticles; synthetic membrane; transdermal
Subjects:	Q Science > QC Physics Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	24 Nov 2021 01:38
URI:	http://gala.gre.ac.uk/id/eprint/30372

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