Angulo Pinzon, O.A., Bradley, Michael, Berry, Robert and Farnish, Richard J. (2008) Modelling dosator filling and discharge of powder. Proceedings of the International Symposium Reliable Flow of Particulate Solids IV (RELPOWFLO IV) (Tromso, Norway 10-12 June, 2008). Telemark University College, Telemark, pp. 586-591. ISBN 9788272062896

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Abstract

Dosators and other dosing mechanisms operating on generally similar principles are very widely used in the pharmaceutical industry for capsule filling, and for dosing products that are delivered to the customer in powder form such as inhalers. This is a trend that is set to increase. However a significant problem for this technology is being able to predict how accurately and reliably, new drug formulations will be dosed from these machines prior to manufacture. This paper presents a review of the literature relating to powder dosators which considers mathematical models for predicting dosator performance, the effects of the dosator geometry and machine settings on the accuracy of the dose weight. An overview of a model based on classical powder mechanics theory that has been developed at The University of Greenwich is presented. The model uses inputs from a range of powder characterisation tests including, wall friction, bulk density, stress ratio and permeability. To validate the model it is anticipated that it will be trialled for a range of powders alongside a single shot dosator test rig.

Item Type:	Book Section
Additional Information:	This paper was given at the International Symposium Reliable Flow of Particulate Solids IV (RELPOWFLO IV) 10th – 12th June 2008 held in Tromsø, Norway - it was also given at the Particulate System Analysis Conference, Stratford-Upon-Avon, Warwickshire, UK, 2-4 September 2008
Uncontrolled Keywords:	dosators, powders
Subjects:	T Technology > T Technology (General) T Technology > TP Chemical technology T Technology > TS Manufactures
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Related URLs:	Organisation Organisation Organisation Organisation Organisation Organisation
Last Modified:	28 Jan 2020 11:39
URI:	http://gala.gre.ac.uk/id/eprint/2621

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