Gerratt, A.H.N., Ahmad, S., Graham, K., Patel, S.P., Webb, J.R. and Stokes, T.C. (2007) Survival in 176 patients with inoperable non small cell lung cancer treated initially with chemotherapy in a district general hospital. In: British Thoracic Society Winter Meeting 2007, 6 Dec 2007, London, UK.

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Abstract

In advanced non-small cell lung cancer (NSCLC) platinum based chemotherapy with second generation drugs improves median survival (MS) to 8 months and 29% and 10% at 1 and 2 years. Platinum with a third generation drug can improve survival further (BMJ 1995;311: 899) (Spiro et al. Thorax 2004;59:828 Big Lung Trial; N Engl J Med 2003;346:92 ECOG study). NICE now recommends chemotherapy with platinum and a third generation drug for inoperable NSCLC as the first treatment modality.

Methods: We audited survival of 176/461 consecutive patients referred for at least 3 courses of platinum and either gemcitabine or vinorelbine from July 2001 to December 2005. Minimal follow up 17 months. Chemotherapy was given on site. Radical radiotherapy for stage IIIA, palliative radiotherapy and second line drugs were given as felt appropriate.

Results: 64% were male. 30 (17%) were <55 years ; 66 (37.5%) age 55–65 years; 63 (35.8%) aged 66–75 and 16 (9.1%) >75 years. 5 (2.8%) were stage II; 46 (26%) stage IIIA; 68 (38%) stage IIIB and 55 (30.8%) stage IV. 68 (38%) had 0– 2 courses; 63 (36%) 3 courses and 44 (25%) had 4 or more.

Item Type:	Conference or Conference Paper (Paper)
Additional Information:	[1] This paper was first presented at the British Thoracic Society Winter Meeting 2007 held on 5–7 December 2007 in London, UK. [2] An abstract of this paper from the Spoken Sessions was published in Thorax 2007, Vol 62; Supplement 3, Abstract S86. Thorax is the official journal of the British Thoracic Society (BTS). Thorax is co-owned by the British Thoracic Society (BTS) and BMJ Publishing Group. ISSN: 0040-6376 (Print); 1468-3296 (Online).
Uncontrolled Keywords:	survival, patients, inoperable non small cell lung cancer, chemotherapy, district general hospital
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Pre-2014 Departments:	School of Health & Social Care School of Health & Social Care > Department of Psychology & Counselling
Related URLs:	Organisation Organisation Organisation
Last Modified:	14 Oct 2016 09:07
URI:	http://gala.gre.ac.uk/id/eprint/2588

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