Uddi, Md Jasim, Scoutaris, Nikolaos, Economidou, Sophia N., Giraud, Clementine, Chowdhry, Babur, Donnelly, Ryan F. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2019) 3D printed microneedles for anticancer therapy of skin tumours. Materials Science and Engineering: C, 107:110248. ISSN 0928-4931 (Print), 1873-0191 (Online) (doi:https://doi.org/10.1016/j.msec.2019.110248)

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Abstract

In this study, novel 3D printed polymeric microneedle arrays were fabricated for enhanced cisplatin delivery to A-431 epidermoid skin tumours for cancer treatment. The microneedles were built by selectively photopolymerising consecutive layers of a biocompatible photopolymer resin using stereolithography (SLA), followed by coating of cisplatin formulations using inkjet dispensing on the needle surface. The printability via SLA was optimized to improve microneedle mechanical properties and optical coherence tomography analysis showed excellent piercing capacity of 3D printed microneedles to an 80% penetration depth. Franz cell diffusion studies revealed rapid cisplatin release rates of 80–90% within 1 h and in vivo evaluation with Balb/c nude mice presented sufficient cisplatin permeabilization with high anticancer activity and tumour regression. Histopathology analysis confirmed the tumour inhibition effect, showing demarcated lesions with thin fibrous capsules and necrotic cores. The use of 3D printed microneedles demonstrates the potential for in-vivo transdermal delivery of anticancer drugs.

Item Type:	Article
Additional Information:	** Article version: AM ** Embargo end date: 31-12-9999 ** From Elsevier via Jisc Publications Router ** History: accepted 23-09-2019; issue date 12-10-2019. ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised.
Uncontrolled Keywords:	3D printing; stereolithography; microneedles; anticancer delivery; tumour regression
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Medway Centre for Pharmaceutical Science > Pharmaceutical and Medicinal Science Research Group Faculty of Engineering & Science > Medway School of Pharmacy Faculty of Engineering & Science > School of Science (SCI)
SWORD Depositor:	Users 6393 not found.
Last Modified:	12 Jun 2024 16:13
URI:	http://gala.gre.ac.uk/id/eprint/25580

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