Ajiboye, Adejumoke Lara, Trivedi, Vivek ORCID: https://orcid.org/0000-0001-9304-9214 and Mitchell, John C. ORCID: https://orcid.org/0000-0003-2945-3292 (2017) Preparation of polycaprolactone nanoparticles via supercritical carbon dioxide extraction of emulsions. Drug Delivery and Translational Research. pp. 1-7. ISSN 2190-393X (Print), 2190-3948 (Online) (doi:10.1007/s13346-017-0422-3)

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Abstract

Polycaprolactone (PCL) nanoparticles were produced via supercritical fluid extraction of emulsions (SFEE) using supercritical carbon dioxide (scCO2). The efficiency of the scCO2 extraction was investigated and compared to that of solvent extraction at atmospheric pressure. The effects of process parameters including polymer concentration (0.6–10% w/w in acetone), surfactant concentration (0.07 and 0.14% w/w) and polymer-to-surfactant weight ratio (1:1–16:1 w/w) on the particle size and surface morphology were also investigated. Spherical PCL nanoparticles with mean particle sizes between 190 and 350 nm were obtained depending on the polymer concentration, which was the most important factor where increase in the particle size was directly related to total polymer content in the formulation. Nanoparticles produced were analysed using dynamic light scattering and scanning electron microscopy. The results indicated that SFEE can be applied for the preparation of PCL nanoparticles without agglomeration and in a comparatively short duration of only 1 h.

Item Type:	Article
Additional Information:	© The Author(s) 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords:	Solvent extraction; Polycaprolactone; Nanoparticles; Supercritical carbon dioxide; Supercritical fluid extraction of emulsions
Subjects:	Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	01 Sep 2017 16:03
URI:	http://gala.gre.ac.uk/id/eprint/17589

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