Tran, Q., Le, T., Le, C. H. ORCID: https://orcid.org/0000-0002-5168-2297 and Vo, T. V. (2017) Electrophysiological modeling in generalized epilepsy using surface EEG and anatomical brain structures. In: 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6). IFMBE Proceedings, 63 . Springer Nature Singapore Pte Ltd, pp. 699-704. ISBN 978-981-10-4360-4 ISSN 1680-0737 (doi:10.1007/978-981-10-4361-1_120)

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Abstract

Deep brain structures involve significantly in the pathology of brain diseases such as epilepsy, Alzheimer, and Parkinson. Physiological brain modeling has become an emerging approach to investigate the coupling dynamics of the brain activity ofthese diseases. We propose a method using the surface EEG signals integrated with the anatomical individual brain to build the electrophysiological model of the epileptic patient’s brain. The EEG-driven model is used to investigate the deep brain activities of 23 patients diagnosed with generalized epilepsy from CHB-MIT Scalp EEG Database. Significant changes in the electrical activities in hippocampus, accumbens, amygdala, provide us insights into the dynamics ofactive brain regions during epilepsy. All of these brain regions show the significant energy variation defined by 5 features (Mean, Max, Min, Standard deviation, Power spectral density) with the p-value < 0.05 in both pre-ictal vs ictal and ictal vs post-ictal. Such result shows the potential of using EEG as a tool to capture the deep brain activity of epilepsy and other diseases that alter deep brain structures. The proposed model may be used to enhance the sensitivity of detecting and predicting epilepsy, detect the progression of the brain lesion, and support the decision-making for a brain medical intervention.

Item Type:	Conference Proceedings
Title of Proceedings:	6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6)
Additional Information:	Presented at the 6th International Conference on the Development of Biomedical Engineering, Ho Chi Minh City, Vietnam, June 27-29 2016
Uncontrolled Keywords:	Electrophysiological model; Generalized epilepsy; Deep brain structures; Deep brain activity
Subjects:	B Philosophy. Psychology. Religion > BF Psychology T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Engineering (ENG)
Related URLs:	Organisation Publisher
Last Modified:	18 Sep 2020 23:36
URI:	http://gala.gre.ac.uk/id/eprint/17479

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