Al-Kurdi, Zakieh, Chowdhry, Babur Z., Leharne, Stephen A., Omari, Mahmoud and Badwan, Adnan (2015) Low molecular weight chitosan–insulin polyelectrolyte complex: characterization and stability studies. Marine Drugs, 13 (4). pp. 1765-1784. ISSN 1660-3397 (doi:10.3390/md13041765)

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Abstract

The aim of the work reported herein was to investigate the effect of various low molecular weight chitosans (LMWCs) on the stability of insulin using USP HPLC methods. Insulin was found to be stable in a polyelectrolyte complex (PEC) consisting of insulin and LMWC in the presence of a Tris-buffer at pH 6.5. In the presence of LMWC, the stability of insulin increased with decreasing molecular weight of LMWC; 13 kDa LMWC was the most efficient molecular weight for enhancing the physical and chemical stability of insulin. Solubilization of insulin-LMWC polyelectrolyte complex (I-LMWC PEC) in a reverse micelle (RM) system, administered to diabetic rats, results in an oral delivery system for insulin with acceptable bioactivity.

Item Type:	Article
Additional Information:	[1] Copyright: (c) 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). [2] This article belongs to the Special Issue Advances in Marine Chitin and Chitosan.
Uncontrolled Keywords:	insulin, oligochitosan, low molecular weight chitosan, polyelectrolyte complex, stability
Subjects:	Q Science > Q Science (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science
Related URLs:	Publisher
Last Modified:	15 Oct 2016 17:08
URI:	http://gala.gre.ac.uk/id/eprint/13603

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