Boateng, Joshua ORCID: 0000-0002-6310-729X, Burgos-Amador, Rocio, Okeke, Obinna and Pawar, Harshavardhan (2015) Composite alginate and gelatin based bio-polymeric wafers containing silver sulfadiazine for wound healing. International Journal of Biological Macromolecules, 79. pp. 63-71. ISSN 0141-8130 (doi:https://doi.org/10.1016/j.ijbiomac.2015.04.048)

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Abstract

Lyophilized wafers comprising sodium alginate (SA) and gelatin (GE) (0/100, 75/25, 50/50, 25/75, 0/100 SA/GE, respectively) with silver sulfadiazine (SSD, 0.1% w/w) have been developed for potential application on infected chronic wounds. Polymer–drug interactions and physical form were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), respectively, while morphological structure was examined using scanning electron microscopy (SEM). Functional characteristics [(mechanical hardness and adhesion using texture analyzer, and swelling capacity)] of blank wafers were determined in order to select the optimal formulations for drug loading. Finally, the in vitro drug dissolution properties of two selected drug loaded wafers were investigated. There was an increase in hardness and a decrease in mucoadhesion with increasing GE content. FTIR showed hydrogen bonding and electrostatic interaction between carboxyl of SA and amide of GE but no interaction between the polymers and drug was observed, with XRD showing that SSD remained crystalline during gel formulation and freeze–drying. The results suggest that 75/25 SA/GE formulations are the ideal formulations due to their uniformity and optimal mucoadhesivity and hydration. The drug loaded wafers showed controlled release of SSD over a 7 h period which is expected to reduce bacterial load within infected wounds.

Item Type:	Article
Additional Information:	This is the Author's Accepted Manuscript version, uploaded in accordance with the publisher's self-archiving policy. Please note: this is the author’s version of a work that was accepted for publication in the INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. Changes resulting from the publishing process, such as editing, structural formatting, and other quality control mechanisms may not be reflected in this document. The definitive version is available at: http://dx.doi.org/10.1016/j.ijbiomac.2015.04.048.
Uncontrolled Keywords:	bio-polymeric, wafers, wound healing
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	17 Oct 2016 09:13
URI:	http://gala.gre.ac.uk/id/eprint/13524

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