Ahmed, Salman, Hasan, Muhammad Mohtasheemul, Ahmed, Syed Waseemuddin, Mahmood, Zafar Alam, Azhar, Iqbal and Habtemariam, Solomon (2013) Anti-emetic effects of bioactive natural products. Phytopharmacology, 4 (2). pp. 390-433. ISSN 2046-1194

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Abstract

Emesis, also known as nausea and vomiting, are common symptoms associatedwith ingestion of toxicants, drug side effects, advanced terminal diseases such ascancer and postoperative procedures. Emesis is mediated through the coordinatedaction of central and peripheral regulatory centres that involve receptors includingdopamine Type 2, serotonin, muscarinic cholinergic, histamine, cannabinoids and NK-1 receptors. Many anti-emetic drugs targeting these receptors are currently inuse but they also cause undesirable side effects such as excessive sedation, hypote-nsion, dry mouth, dysphoria, hallucinations and extrapyramidal signs. This reviewhighlights the pharmacological mechanism of emesis and current antiemtic drugstogether with detailed analysis of in vitro and in vivo anti-emetic bioassay models.The pharmacology of crude natural products extracts and purified anti-emeticcompounds (cannabinoids, chalcones, diarylheptanoids, flavonoids, hydroxycinn-amic acids, lignans, phenylpropanoids, polysaccharides, saponins, terpenes and gly-cosidic derivatives) are also systematically presented with their mechanism of acti-on. The potential of natural products as sources of new clinically proven anti-eme-tic drugs are discussed

Item Type:	Article
Additional Information:	[1] Copyright: © 2013 Inforesights Publishing UK. [2] Phytopharmacology is an international peer-reviewed open-access journal (http://inforesights.com/phytopharmacology/)
Uncontrolled Keywords:	Emesis, anti-emetics, natural products, anti-emetic experimental models, drug development
Subjects:	Q Science > QK Botany
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	17 Oct 2016 09:13
URI:	http://gala.gre.ac.uk/id/eprint/13426

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