Yang, Jin, Tang, Sanyi and Cheke, Robert A. ORCID: 0000-0002-7437-1934 (2015) Modelling pulsed immunotherapy of tumour–immune interaction. Mathematics and Computers in Simulation, 109. pp. 92-112. ISSN 0378-4754 (doi:https://doi.org/10.1016/j.matcom.2014.09.001)

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Abstract

We develop a mathematical model that describes the tumour–immune interaction and the effect on it of pulsed immunotherapy, based on the administration of adoptive cellular immunotherapy (ACI) combined with interleukin-2 (IL-2). The stability conditions for the tumour-free periodic solution are provided with different frequencies of ACI applications and IL-2 infusions. Furthermore, the effects of period, dosage and times of drug deliveries on the amplitudes of the tumour-free periodic solution were investigated. The most feasible immunotherapy strategy was determined by comparing immunotherapy with ACI treatment with or without IL-2. However, to investigate how to enhance the efficacy of chemotherapy (radiotherapy) and reduce its side-effects, we developed a model involving periodic applications of immunotherapy with chemotherapy (radiotherapy) applied only when the density of the tumour reached a given threshold. The results revealed that the initial densities, the effector cell: tumour cell ratios, the periods T and a given critical number of tumour cells CT are crucial for cancer treatment, which confirms that it is important to customize treatment strategies for individual patients.

Item Type:	Article
Uncontrolled Keywords:	cancer, immunotherapy, periodic solution, combined therapy, threshold
Subjects:	Q Science > QA Mathematics > QA76 Computer software R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute
Last Modified:	21 Oct 2016 10:43
URI:	http://gala.gre.ac.uk/id/eprint/12314

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