Lapthorn, Cris, Pullen, Frank, Chowdhry, Babur, Perkins, George, Dines, Trevor and McCullagh, Michael (2014) The effect of charge location in ion mobility mass spectrometry for small molecule analytes. In: 62nd ASMS Conference on Mass Spectrometry and Allied Topics, 15-19 Jun 2014, Baltimore, MD, USA.

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Abstract

In travelling wave IM-MS an electric field is applied across the IMS cell and analyte collisions with the inert gas give rise to a relationship between the drift time and the molecular shape and overall charge.

Recent findings show near baseline IMS separation (R>1) where shape and overall charge appear not to explain the IMS separation. Multiple ion mobility peaks are observed for a single m/z including the fluoroquinolone antibiotics norfloxacin and lomefloxacin, the pesticide indoxacarb and a number of steroids.

Item Type:	Conference or Conference Paper (Poster)
Additional Information:	[1] Poster WP 695 - presented in Ion Mobility: Fundamentals stream. Part of the 62nd ASMS Conference on Mass Spectrometry and Allied Topics, held 15-19 June 2014, Baltimore Convention Center, Baltimore, MD, USA. [2] British Mass Spectrometry Society, April 2014. Prize awarded for 'The effect of charge location in ion mobility mass spectrometry for small molecule analytes', available at http://dx.doi.org/10.6084/m9.figshare.1134183. Judged by Prof. Graham Cooks (Henry Bohn Hass Distinguished Professor of Chemistry at Purdue University, ISI Highly Cited Chemist with over 950 publications and an H-index of 81) and Prof. Mike Morris (‎Senior Director MS Research at Waters).
Uncontrolled Keywords:	charge location, ion mobility mass spectrometry, small molecule analytes
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science
Related URLs:	Organisation Organisation
Last Modified:	14 Oct 2016 09:28
URI:	http://gala.gre.ac.uk/id/eprint/12156

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