Bellantone, M., Coleman, Nichola and Hench, L.L. (2000) Bacteriostatic action of a novel four-component bioactive glass. Journal of Biomedical Materials Research, 51 (3). pp. 484-490. ISSN 0021-9304 (doi:https://doi.org/10.1002/1097-4636(20000905))

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Abstract

Bacterial adhesion to biomaterials causing biomaterial-centered infection and poor tissue integration is a problem that limits the extensive use of many biomaterial devices in clinical applications. Bioactive materials are those biomaterials that form a compliant, mechanically stable bond with host tissue. Sol-gel-derived glasses in the three-component system SiO2-CaO-P2O5 exhibit bioactivity that is dependent on composition and texture (i.e., specific surface area, pore size, structure, and distribution). The in vitro bioactivity and antibacterial action of a novel sol-gel-derived glass, AgBG, in the system SiO2-CaO-P2O5-Ag2O are compared with those of its three-component counterpart, BG. The incorporation of 3-wt % Ag2O conferred antimicrobial properties to the glass without compromising its bioactivity. AgBG exhibited a marked bacteriostatic effect on E. coli MG1655 with a minimum inhibiting concentration of 0.2 mg (biomaterial)/mL (culture solution), above which bacterial growth was reduced to 0.01% of that of the control culture. In comparison, BG did not possess antimicrobial properties over the concentration range investigated (0.1-40.0 mg/mL). (C) 2000 John Wiley & Sons, Inc.

Item Type:	Article
Uncontrolled Keywords:	Bioactive glass, Sol-gel, Antimicrobial, Bacteriostatic, Silver
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science
Last Modified:	14 Oct 2016 09:28
URI:	http://gala.gre.ac.uk/id/eprint/11794

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