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Prostate cancer targeting with 7E11-C5.3-CdS bioconjugated quantum dots

Prostate cancer targeting with 7E11-C5.3-CdS bioconjugated quantum dots

Rajaram, Sudha, Bhujbal, Pranav, Slipper, Ian J., Favretto, Marco E. and Douroumis, Dennis (2013) Prostate cancer targeting with 7E11-C5.3-CdS bioconjugated quantum dots. Journal of Colloid Science and Biotechnology, 2 (1). pp. 34-39. ISSN 2164-9634 (Print), 2164-9642 (Online) (doi:10.1166/jcsb.2013.1036)

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Abstract

The aim of this study was to conjugate water-soluble CdS quantum dots (QDs) suitable for targeting of human prostate cancer cells. The water-soluble QDs were conjugated with transferring (Tf) or the murine monoclonal antibody, 7E11-C5.3 through the free carboxylic groups covalently attached. The conjugated CdS were characterized by luminescence and Bradford assay to confirm the attachment of the molecules on the surface of the semiconductor nanocrystals. Cytotoxicity studies showed increased cell viability of the conjugated QDs compared to plain QDs. The conjugates were used to label LNCaP prostate cancer cells and after 5 hr incubation were localized in the cell nucleus. The results showed that QD-7E11 conjugates could be used for in vivo diagnostic studies.

Item Type: Article
Uncontrolled Keywords: prostate cancer, bioconjugated quantum dots
Subjects: Q Science > QD Chemistry
Pre-2014 Departments: School of Science
Related URLs:
Last Modified: 09 Dec 2016 14:24
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/9984

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