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Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file

Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file

Bell, Andrew S., Bradley, Joseph, Everett, Jeremy R. ORCID: 0000-0003-1550-4482, Knight, Michelle, Loesel, Jens, Mathias, John, McLoughlin, David, Mills, James, Sharp, Robert E., Williams, Christine and Wood, Terence P. (2013) Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file. Molecular Diversity, 17 (2). pp. 319-335. ISSN 1381-1991 (Print), 1573-501X (Online) (doi:10.1007/s11030-013-9438-x)

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Abstract

The screening files of many large companies, including Pfizer, have grown considerably due to internal chemistry efforts, company mergers and acquisitions, external contracted synthesis, or compound purchase schemes. In order to screen the targets of interest in a cost-effective fashion, we devised an easy-to-assemble, plate-based diversity subset (PBDS) that represents almost the entire computed chemical space of the screening file whilst comprising only a fraction of the plates in the collection. of both library chemistry and legacy chemistry space. This paper describes the rationale, design, construction, and performance of the PBDS, that has evolved into the standard paradigm for singleton (one compound per well) high throughput screening in Pfizer since its introduction in 2006.

Item Type: Article
Additional Information: [1] Published online: 5 April 2013. [2] Published in print: 1 May 2013. [3] Published as: Molecular Diversity, May 2013, Volume 17, Issue 2, pp 319-335.
Uncontrolled Keywords: rule of 40 (Ro40), high throughput screening, (HTS), plate based, diversity, subset, screening file
Subjects: Q Science > QD Chemistry
Pre-2014 Departments: School of Science
Last Modified: 18 Oct 2016 11:46
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/9965

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