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LED-array photocalorimetry: instrument design and application to photostability of nifedipine

LED-array photocalorimetry: instrument design and application to photostability of nifedipine

Dhuna, Meena, Beezer, Anthony E., Connor, Joseph A., Clapham, David, Courtice, Chris, Frost, John and Gaisford, Simon (2008) LED-array photocalorimetry: instrument design and application to photostability of nifedipine. Journal of Pharmaceutical and Biomedical Analysis, 48 (5). pp. 1316-1320. ISSN 0731-7085 (doi:10.1016/j.jpba.2008.09.007)

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Abstract

A photocalorimeter was designed to analyse quantitatively the photostability of pharmaceuticals. Its application is demonstrated with reference to two solution phase test systems; the photodegradations of 2-nitrobenzaldehyde (2-NB) and nifedipine. Light emitting diode (LED) arrays were used to illuminate the sample and reference channels of the calorimeter. Five LEDs were used to create an array from 360 to 700 nm. A power supply system was constructed that zeroed the instrument by supplying a preset voltage to the sample side LEDs and varying that supplied to the reference LEDs until a zero calorimetric signal was obtained. The photodegradation of 2-NB was zero-order and varied in proportion to the input voltage supplied to the LED array. Analysis of the data (the rate of reaction was determined to be equal 1.04 × 10−6 mol dm−3 s−1 by pH titration) determined a reaction enthalpy of 5.0 ± 0.6 kJ mol−1. In the case of nifedipine, the LEDs in the array were operated individually in order to determine the causative wavelength of degradation. This was found to be 360 nm, in agreement with the literature.

Item Type: Article
Additional Information: [1] Available online 11 September 2008. [2] A sponsored journal of the American Association of Pharmaceutical Scientists.
Uncontrolled Keywords: isothermal calorimetry, photocalorimetry, light emitting diode (LED), 2-nitrobenzaldehyde, nifedipine
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Pre-2014 Departments: School of Science
School of Science > Medway Sciences Research Group
Related URLs:
Last Modified: 14 Oct 2016 09:22
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/9136

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