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Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?

Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?

Taylor, Lorna J., Brown, Richard G., Tsermentseli, Stella, Al-Chalabi, Ammar, Shaw, Christopher E., Ellis, Catherine M., Leigh, P. Nigel and Goldstein, Laura H. (2012) Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis? Journal of Neurology, Neurosurgery & Psychiatry, 84 (5). pp. 494-498. ISSN 0022-3050 (Print), 1468-330X (Online) (doi:10.1136/jnnp-2012-303526)

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Abstract

Background: Systematic explorations of language abilities in patients with amyotrophic lateral sclerosis (ALS) are lacking in the context of wider cognitive change.

Methodology: Neuropsychological assessment data were obtained from 51 patients with ALS and 35 healthy controls matched for age, gender and IQ. Composite scores were derived for the domains of language and executive functioning. Domain impairment was defined as a composite score ≤5th centile relative to the control mean. Cognitive impairment was also classified using recently published consensus criteria.

Results: The patients with ALS were impaired on language and executive composite scores. Language domain impairment was found in 43% of patients with ALS, and executive domain impairment in 31%. Standardised language and executive composite scores correlated in the ALS group (r=0.68, p<0.001). Multiple regression analyses indicated that scores on the executive composite accounted for 44% of the variance in language composite scores.

Conclusions: Language impairments are at least as prevalent as executive dysfunction in ALS. While the two domains are strongly associated, executive dysfunction does not fully account for the profile of language impairments observed, further highlighting the heterogeneity of cognitive impairment in non-demented patients with ALS.

Item Type: Article
Additional Information: [1] Published Online First 2 October 2012. Published in Journal of Neurology, Neurosurgery & Psychiatry, Volume 84, Issue 5, May 2013.
Uncontrolled Keywords: amyotrophic lateral sclerosis, cognition, language, executive dysfunction
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Pre-2014 Departments: School of Health & Social Care
School of Health & Social Care > Department of Psychology & Counselling
Related URLs:
Last Modified: 14 Oct 2016 09:22
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/8927

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