Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi
Temperton, Nigel J., Wilkinson, Shane R. and Kelly, John M. (1996) Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi. Molecular and Biochemical Parasitology, 76 (1-2). pp. 339-343. ISSN 0166-6851 (doi:10.1016/0166-6851(95)02553-7)Full text not available from this repository.
Development of new chemotherapeutic agents against Chagas’ disease is a major WHO objective [I]. Drugs currently in use, such as nifurtimox, often have serious side effects and can fail to eradicate parasitemia . The trypanocidal effects of nifurtimox are thought to be mediated through the generation of nitro-radicals which promote the formation of toxic oxygen metabolites within the parasite [3,4]. Oxidative stress resulting from the generation of the superoxide radical has also been implicated as a mechanism of action of gentian violet, an agent employed to prevent transmission of Chagas’ disease by blood transfusion
[5,6]. Thus, identification and functional analysis of Trypanosoma cruzi enzymes involved in antioxidant defence could be of importance in the context of improved chemotherapeutic approaches.
|Additional Information:|| Nucleotide sequence data reported in this paper are available in the GenBank database with accession number U39401.|
|Uncontrolled Keywords:||Trypanosoma cruzi, iron superoxide dismutase, oxidative stress|
|Subjects:||Q Science > QH Natural history > QH426 Genetics|
R Medicine > RC Internal medicine
|School / Department / Research Groups:||Medway School of Pharmacy|
|Last Modified:||16 Jul 2012 15:23|
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