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Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi

Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi

Temperton, Nigel, Wilkinson, Shane R. and Kelly, John M. (1996) Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi. Molecular and Biochemical Parasitology, 76 (1-2). pp. 339-343. ISSN 0166-6851 (doi:10.1016/0166-6851(95)02553-7)

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Abstract

Development of new chemotherapeutic agents against Chagas’ disease is a major WHO objective [I]. Drugs currently in use, such as nifurtimox, often have serious side effects and can fail to eradicate parasitemia [2]. The trypanocidal effects of nifurtimox are thought to be mediated through the generation of nitro-radicals which promote the formation of toxic oxygen metabolites within the parasite [3,4]. Oxidative stress resulting from the generation of the superoxide radical has also been implicated as a mechanism of action of gentian violet, an agent employed to prevent transmission of Chagas’ disease by blood transfusion [5,6]. Thus, identification and functional analysis of Trypanosoma cruzi enzymes involved in antioxidant defence could be of importance in the context of improved chemotherapeutic approaches.

Item Type: Article
Additional Information: [1] Nucleotide sequence data reported in this paper are available in the GenBank database with accession number U39401.
Uncontrolled Keywords: Trypanosoma cruzi; Iron superoxide dismutase; Oxidative stress
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Medway School of Pharmacy
Related URLs:
Last Modified: 03 Jan 2017 14:26
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/8572

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