Skip navigation

Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins

Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins

Ayensu, Isaac, Mitchell, John C. ORCID: 0000-0003-2945-3292 and Boateng, Joshua S. ORCID: 0000-0002-6310-729X (2012) Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules, 50 (4). pp. 905-909. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2012.02.014)

Full text not available from this repository.

Abstract

The effect of membrane dialysis on the characteristics of chitosan based lyophilised wafers was investigated. Gels loaded with BSA, glycerol and d-mannitol were lyophilised with or without membrane dialysis and characterised by X-ray diffraction, attenuated total reflectance Fourier transform infra red spectroscopy, circular dichroism, scanning electron microscopy, hydration capacity, in vitro mucoadhesivity and drug dissolution. The dialysed wafers demonstrated enhanced mucoadhesion and drug release properties while newly formed sodium acetate in the undialysed wafers caused increased crystallinity with poor mucoadhesion and drug release properties. Removal of sodium acetate by membrane dialysis is essential for obtaining optimised wafers for potential application to the buccal mucosa surface.

Item Type: Article
Uncontrolled Keywords: buccal delivery, chitosan, lyophilised wafers, membrane dialysis, mucoadhesion, protein delivery
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:11
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/8236

Actions (login required)

View Item View Item