Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library
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Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039
Full text not available from this repository.Official URL: http://dx.doi.org/10.1016/j.tetlet.2012.01.081
Abstract
A 2-substituted-5-aminooxazole-4-carbonitrile library has been synthesised and modified via microwave-mediated and flow chemistries. One synthesised compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | microwave-assisted synthesis, oxazoles, parallel synthesis, flow chemistry |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| School / Department / Research Groups: | School of Science School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences |
| Related URLs: | |
| Last Modified: | 02 Mar 2012 09:32 |
| URI: | http://gala.gre.ac.uk/id/eprint/7695 |
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