Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library
Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.01.081)Full text not available from this repository.
A 2-substituted-5-aminooxazole-4-carbonitrile library has been synthesised and modified via microwave-mediated and flow chemistries. One synthesised compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors.
|Uncontrolled Keywords:||microwave-assisted synthesis, oxazoles, parallel synthesis, flow chemistry|
|Subjects:||Q Science > Q Science (General)|
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||02 Mar 2012 09:32|
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