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A novel pentacyclic triterpene glycoside from a resin of Commiphora glandulosa from Botswana

A novel pentacyclic triterpene glycoside from a resin of Commiphora glandulosa from Botswana

Motlhanka, Daniel, Houghton, Peter, Miljkovic-Brake, Ana and Habtemariam, Solomon (2010) A novel pentacyclic triterpene glycoside from a resin of Commiphora glandulosa from Botswana. African Journal of Pharmacy and Pharmacology, 4 (8). pp. 549-554. ISSN 1996 0816

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Abstract

A novel ursane-type pentacyclic triterpene glycoside, 1b,2b,3b-trihydoxy-urs-12-ene-23-oic-rhamnoside was isolated from the resin of Commiphora glandulosa Schinz by bioassay guided fractionation. Crude aqueous and chloroform extracts of the resin as well as the isolated compound exhibited good in vitro antibacterial activity against gram positive bacteria (Bacillus subtilis: NCTC 10073), (Clostridium perfringens: NCTC 8237), (Staphylococcus aureus: NCIMB 9518) and also drug resistant strains (S.aureus:XU212-tetracycline resistant strain), (S. aureus SA1199B-norfloxacin resistant strain). There was no observed antimicrobial activity against gram negative bacteria (Escherichia coli: NCTC 9002), (Pseudomonas aeruginosa: NCIMB 10421), (Klebsiella aerogenes: NCTC 5055); and fungal strains (Candida albicans: NCPF 3179, Aspergillus fumigatus: NCPF 7097), Trichophyton tonsurans: NCPF 995). The structure of the isolated compound was elucidated on the basis of spectral data using13CNMR, 1H-NMR and mass spectroscopy.

Item Type: Article
Uncontrolled Keywords: Commiphora glandulosa resins, antibacterial activity, novel pentacyclic triterpene, Botswana medicinal plants, antibacterial activity
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 08 Dec 2016 12:04
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/7642

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