Preparation and characterization of a novel co-processed excipient of chitin and crystalline mannitol
Daraghmeh, Nidal, Rashid, Iyad, Al Omari, Mahmoud M.H., Leharne, Stephen A., Chowdhry, Babur Z. and Badwan, Adnan (2010) Preparation and characterization of a novel co-processed excipient of chitin and crystalline mannitol. Biomedical and Life Sciences: American Association of Pharmaceutical Scientists, 11 (4). pp. 1558-1571. ISSN 1530-9932 (Online) (doi:10.1208/s12249-010-9523-8)Full text not available from this repository.
A co-processed excipient was prepared from commercially available crystalline mannitol and α-chitin using direct compression as well as spray, wet, and dry granulation. The effect of the ratio of the two components, percentage of lubricant and particle size, on the properties of the prepared co-processed excipient has been investigated. α-Chitin forms non-hygroscopic, highly compactable, disintegrable compacts when co-processed with crystalline mannitol. The compaction properties of the co-processed mannitol–chitin mixture were found to be dependent upon the quantity of mannitol added to chitin, in addition to the granulation procedure used. Optimal physicochemical properties of the excipient, from a manufacturing perspective, were obtained using a co-processed mannitol chitin (2:8, w/w) mixture prepared by wet granulation (Cop MC). Disintegration time, crushing strength, and friability of tablets, produced from Cop-MC using magnesium stearate as a lubricant, were found to be independent of the particle size of the prepared granules. The inherent binding and disintegration properties of the compressed Cop-MC are useful for the formulation of poorly compressible, high strength, and lowstrength active pharmaceutical ingredients. The ability to co-process α-chitin with crystalline mannitol allows chitin to be used as a valuable industrial pharmaceutical excipient.
|Uncontrolled Keywords:||binder, chitin, co-processing, disintegrant, mannitol|
|Subjects:||R Medicine > R Medicine (General)|
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||17 Jul 2012 16:37|
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