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Preparation and characterization of a novel co-processed excipient of chitin and crystalline mannitol

Preparation and characterization of a novel co-processed excipient of chitin and crystalline mannitol

Daraghmeh, Nidal, Rashid, Iyad, Al Omari, Mahmoud M.H., Leharne, Stephen A., Chowdhry, Babur Z. and Badwan, Adnan (2010) Preparation and characterization of a novel co-processed excipient of chitin and crystalline mannitol. Biomedical and Life Sciences: American Association of Pharmaceutical Scientists, 11 (4). pp. 1558-1571. ISSN 1530-9932 (Online) (doi:10.1208/s12249-010-9523-8)

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Abstract

A co-processed excipient was prepared from commercially available crystalline mannitol and α-chitin using direct compression as well as spray, wet, and dry granulation. The effect of the ratio of the two components, percentage of lubricant and particle size, on the properties of the prepared co-processed excipient has been investigated. α-Chitin forms non-hygroscopic, highly compactable, disintegrable compacts when co-processed with crystalline mannitol. The compaction properties of the co-processed mannitol–chitin mixture were found to be dependent upon the quantity of mannitol added to chitin, in addition to the granulation procedure used. Optimal physicochemical properties of the excipient, from a manufacturing perspective, were obtained using a co-processed mannitol chitin (2:8, w/w) mixture prepared by wet granulation (Cop MC). Disintegration time, crushing strength, and friability of tablets, produced from Cop-MC using magnesium stearate as a lubricant, were found to be independent of the particle size of the prepared granules. The inherent binding and disintegration properties of the compressed Cop-MC are useful for the formulation of poorly compressible, high strength, and lowstrength active pharmaceutical ingredients. The ability to co-process α-chitin with crystalline mannitol allows chitin to be used as a valuable industrial pharmaceutical excipient.

Item Type: Article
Uncontrolled Keywords: binder, chitin, co-processing, disintegrant, mannitol
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 16:09
URI: http://gala.gre.ac.uk/id/eprint/7623

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