Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors
Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)Full text not available from this repository.
A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.
|Uncontrolled Keywords:||ferrocene-based 1,2,3-triazole-containing hydroxamic acids, click chemistry, HDAC inhibition and activity|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
|Faculty / Department / Research Groups:||Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences|
|Last Modified:||06 Dec 2016 16:05|
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