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Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Potta, Sriharsha Gupta, Minemi, Sriharsha, Nukala, Ravi Kumar, Peinado, Chairmane, Lamprou, Dimitios A., Urquhart, Andrew and Douroumis, D. (2011) Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation, 28 (1). pp. 74-81. ISSN 0265-2048 (Print), 1464-5246 (Online) (doi:10.3109/02652048.2010.529948)

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Abstract

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.

Item Type: Article
Uncontrolled Keywords: Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:11
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/7576

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