Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility
Potta, Sriharsha Gupta, Minemi, Sriharsha, Nukala, Ravi Kumar, Peinado, Chairmane, Lamprou, Dimitios A., Urquhart, Andrew and Douroumis, D. (2011) Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation, 28 (1). pp. 74-81. ISSN 0265-2048 (print), 1464-5246 (electronic) (doi:10.3109/02652048.2010.529948)Full text not available from this repository.
Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.
|Uncontrolled Keywords:||Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity|
|Subjects:||R Medicine > R Medicine (General)|
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||23 Apr 2012 12:37|
Actions (login required)