A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside
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Habtemariam, S. (2011) A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside. Natural Product Communications, 6 (2). pp. 201-203. ISSN 1934-578X (Printed), 1555-9475 (Online)
Full text not available from this repository.Abstract
Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies. A related structural analogue, kaempferol-3-O-rutinoside (KR) however has not yet been studied for such biological effects. It was found that KR is a potent inhibitor of alpha-glucosidase in vitro with over 8-times more activity than the reference antidiabetic drug, acarbose. Furthermore, KR displayed a synergistic effect with a less potent flavonoid aglycones, kaempferol and quercetin. The structure-activity profile of these drugs and implications of drug combinations are discussed
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | kaempferol, quercetin, rutin |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| School / Department / Research Groups: | School of Science School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences |
| Related URLs: | |
| Last Modified: | 21 Feb 2012 11:53 |
| URI: | http://gala.gre.ac.uk/id/eprint/7522 |
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