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A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside

A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside

Habtemariam, S. (2011) A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside. Natural Product Communications, 6 (2). pp. 201-203. ISSN 1934-578X (Printed), 1555-9475 (Online)

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Abstract

Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies. A related structural analogue, kaempferol-3-O-rutinoside (KR) however has not yet been studied for such biological effects. It was found that KR is a potent inhibitor of alpha-glucosidase in vitro with over 8-times more activity than the reference antidiabetic drug, acarbose. Furthermore, KR displayed a synergistic effect with a less potent flavonoid aglycones, kaempferol and quercetin. The structure-activity profile of these drugs and implications of drug combinations are discussed

Item Type: Article
Uncontrolled Keywords: kaempferol, quercetin, rutin
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 11:50
URI: http://gala.gre.ac.uk/id/eprint/7522

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