The influence of sodium carboxymethylcellulose on drug release from polyethylene oxide extended release matrices
Palmer, Dasha, Levina, Marina, Nokhodchi, Ali, Douroumis, Denny, Farrell, Tom and Rajabi-Siahboomi, Ali (2011) The influence of sodium carboxymethylcellulose on drug release from polyethylene oxide extended release matrices. AAPS PharmSci Tech, 12 (3). pp. 862-871. ISSN 1530-9932 (Online) (doi:10.1208/s12249-011-9648-4)Full text not available from this repository.
Anionic polymer sodium carboxymethylcellulose (CELLOGEN® HP-HS and/or HP-12HS)was investigated for its ability to inﬂuence the release of three model drugs propranolol hydrochloride, theophylline and ibuprofen from polyethylene oxide (POLYOX™ WSR 1105 and/or Coagulant) hydrophilic matrices. For anionic ibuprofen and non-ionic theophylline, no unusual/unexpected release proﬁles were obtained from tablets containing a mixture of two polymers. However, for cationic propranolol HCl, a combination of polyethylene oxide (PEO) with sodium carboxymethylcellulose (NaCMC) produced a signiﬁcantly slower drug release compared to the matrices with single polymers. The potential use of this synergistic interaction can be a design of new extended release pharmaceutical dosage forms with a more prolonged release (beyond 12 h) using lower polymer amount, which could be particularly beneﬁcial for freely water-soluble drugs, preferably for once daily oral administration. In order to explain changes in the obtained drug release proﬁles, Fourier transform infrared absorption spectroscopy was performed. A possible explanation for the more prolonged propranolol HCl release from matrices based on both PEO and NaCMC may be due to a chemical bond(i.e. ionic/electrostatic intermolecular interaction) between amine group of the cationic drug and carboxyl group of the anionic polymer, leading to a formation of a new type/form of the active (i.e. salt) with sustained release pattern.
|Uncontrolled Keywords:||extended release, FT-IR, ibuprofen, matrix tablet, polyethylene oxide, polymer combination, propranolol hydrochloride, sodium carboxymethylcellulose, theophylline|
|Subjects:||Q Science > Q Science (General)|
R Medicine > RM Therapeutics. Pharmacology
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||13 Feb 2012 10:02|
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