Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion
Gryczke, Andreas, Schminke, Silke, Maniruzzaman, Mohammed, Beck, Julien and Douroumis, Dennis (2011) Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids and Surfaces B: Biointerfaces, 86 (2). pp. 275-284. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2011.04.007)Full text not available from this repository.
In the current study Ibuprofen was embedded in a methacrylate copolymer (Eudragit® EPO) matrix to produce solid dispersions by hot-melt extrusion (HME) processing. The obtained granules were incorporated in orally disintegrating tablets (ODTs). The tablets were developed by varying the ratio of superdisintegrants such as sodium croscarmellose and crosslinked polyvinylpyrrolidone grades while a direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets which included porosity, hardness, friability and dissolution profiles were further evaluated and compared with Nurofen® Meltlet ODTs. The taste and sensory evaluation in human volunteers demonstrated excellence in masking the bitter active and improved tablet palatability.
|Additional Information:|| First available online 13 April 2011.  Published in Colloids and Surfaces B: Biointerfaces, Volume 86, Issue 2, 1 September 2011.|
|Uncontrolled Keywords:||hot-melt extrusion, taste masking, orally disintegrating tablets, Eudragit EPO|
|Subjects:||R Medicine > R Medicine (General)|
R Medicine > RA Public aspects of medicine
R Medicine > RM Therapeutics. Pharmacology
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||24 May 2013 15:37|
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