Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries
Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)Full text not available from this repository.
A library of pyridines and pyrimidines has been synthesised in excellent yields employing microwave and flow chemistry methodologies. Work-up bottlenecks have been facilitated substantially by the use of supported reagents and many of the final compounds have been studied in the solid state by single crystal X-ray diffraction.
|Uncontrolled Keywords:||heterocycles, microwaves, parallel synthesis, piperazines, flow chemistry|
|Subjects:||Q Science > QD Chemistry|
|Faculty / Department / Research Groups:||Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences|
|Last Modified:||07 Dec 2016 14:49|
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