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Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)

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Abstract

A library of pyridines and pyrimidines has been synthesised in excellent yields employing microwave and flow chemistry methodologies. Work-up bottlenecks have been facilitated substantially by the use of supported reagents and many of the final compounds have been studied in the solid state by single crystal X-ray diffraction.

Item Type: Article
Uncontrolled Keywords: heterocycles, microwaves, parallel synthesis, piperazines, flow chemistry
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 14:49
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/7382

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