The therapeutic potential of Berberis darwinii Stem-bark: Quantification of berberine and in vitro evidence for Alzheimer's disease therapy
Habtemariam, Solomon (2011) The therapeutic potential of Berberis darwinii Stem-bark: Quantification of berberine and in vitro evidence for Alzheimer's disease therapy. Natural Product Communications, 6 (8). pp. 1089-1090. ISSN 1934-578X (Print), 1555-9475 (Online)Full text not available from this repository.
Berberis darwinii is native to South America but has been widely distributed in Europe and other continents following its discovery by Charles Darwin. Herewith, the therapeutic potential of stem-bark of the plant for treating Alzheimer's disease was studied using an in vitro acetylcholinesterase inhibition assay. It was found that the methanolic extract of the stem-bark was a potent inhibitor of the enzyme with an IC50 value of 1.23 ± 0.05 μg/mL. An HPLC-based berberine quantification study revealed an astonishing 38% yield of the dried methanolic extract.
|Uncontrolled Keywords:||Acetylcholinesterase, Alzheimer's disease, Berberidaceae, Berberine, Berberis darwinii|
|Subjects:||R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
|Faculty / Department / Research Groups:||Faculty of Engineering & Science|
|Last Modified:||14 Oct 2016 09:18|
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