Skip navigation

Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process

Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process

Schafroth, Nina, Arpagaus, Cordin, Jadhava, Umesh Y., Makne, Sushil and Douroumis, Dennis (2012) Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids and Surfaces B: Biointerfaces, 90 (1). pp. 8-15. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2011.09.038)

Full text not available from this repository.

Abstract

In the current study nano and microparticle engineering of water insoluble drugs was conducted using a novel piezoelectric spray-drying approach. Cyclosporin A (CyA) and dexamethasone (DEX) were encapsulated in biodegradable poly(d,l-lactide-co-glycolide) (PLGA) grades of different molecular weights. Spray-drying studies carried out with the Nano Spray Dryer B-90 employed with piezoelectric driven
actuator. The processing parameters including inlet temperature, spray mesh diameter, sample flow rate, spray rate, applied pressure and sample concentration were examined in order to optimize the particle size and the obtained yield. The process parameters and the solute concentration showed a profound effect on the particle engineering and the obtained product yield. The produced powder presented consistent and reproducible spherical particles with narrow particle size distribution. Cyclosporin was found to be molecularly dispersed while dexamethasone was in crystalline state within the PLGA nanoparticles. Further evaluation revealed excellent drug loading, encapsulation efficiency and production yield. In vitro studies demonstrated sustained release patterns for the active substances. This novel spray-drying process
proved to be efficient for nano and microparticle engineering of water insoluble active substances.

Item Type: Article
Uncontrolled Keywords: spray-drying, nanoparticles, microparticles, biodegradable polymers, encapsulation
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Pre-2014 Departments: School of Science
Related URLs:
Last Modified: 14 Oct 2016 09:18
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/7301

Actions (login required)

View Item View Item