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Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs

Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs

Kianfar, Farnoosh, Chowdhry, Babur Z., Antonijevic, Milan D. and Boateng, Joshua S. ORCID: 0000-0002-6310-729X (2012) Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs. Drug Development and Industrial Pharmacy, 38 (10). pp. 1207-1220. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2011.644294)

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Abstract

Bioadhesive buccal films are innovative dosage forms with the ability to adhere to the mucosal surface and subsequently hydrate to release and deliver drugs across the buccal membrane. This study aims to formulate and characterize stable carrageenan (CAR) based buccal films with desirable drug loading capacity. The films were prepared using CAR, poloxamer (POL) 407, various grades of PEG (plasticizer) and loaded with paracetamol (PM) and indomethacin (IND) as model soluble and insoluble drugs, respectively. The films were characterized by texture analysis, thermogravimetric analysis (TGA), DSC, scanning electron microscopy, X-ray powder diffraction (XRPD), and in vitro drug release studies. Optimized films were obtained from aqueous gels comprising 2.5% w/w κ-CAR 911, 4% w/w POL 407 and 6% w/w (PM) and 6.5% w/w (IND) of PEG 600 with maximum drug loading of 1.6% w/w and 0.8 % w/w for PM and IND, respectively. TGA showed residual water content of approximately 5% of films dry weight. DSC revealed a Tg at 22.25 and 30.77°C for PM and IND, respectively, implying the presence of amorphous forms of both drugs which was confirmed by XRPD. Drug dissolution profiles in simulated saliva showed cumulative percent release of up to 45 and 57% of PM and IND, respectively, within 40 min of contact with dissolution medium simulating saliva.

Item Type: Article
Additional Information: [1] Published early online 1 December 2011. [2] Published in print: October 2012. [3] Published in Drug Development and Industrial Pharmacy, Vol. 38, No. 10, Pages 1207-1220.
Uncontrolled Keywords: carrageenan, plasticizer, physical characterization, solvent cast films, tensile properties, indomethacin, paracetamol
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 06 Dec 2016 15:21
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/7196

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