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Investigations on air induced segregation of pharmaceutical powders and effect of material flow functions

Investigations on air induced segregation of pharmaceutical powders and effect of material flow functions

Deng, Tong, Paul, Kirsty A., Bradley, Michael S.A., Immins, Lee, Preston, Chris, Scott, Jerry F. and Welfare, Eloise H. (2010) Investigations on air induced segregation of pharmaceutical powders and effect of material flow functions. Powder Technology, 203 (2). pp. 354-358. ISSN 0032-5910 (doi:10.1016/j.powtec.2010.05.028)

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Abstract

For the pharmaceutical industry, powder segregation can occur in many processes such as blending and compression solid dose unit operations. Yet it is important that the high quality standards of drug product manufacture are maintained throughout the whole processes. Powder segregation has been identified by the pharmaceutical industry as a potential issue, and in some cases it may cause variability in tablet assay and uniformity throughout a compression run. Early studies suggested for certain Direct Compression (DC) products, the separation of Active Pharmaceutical Ingredient (API) from excipients could arise due to air-induced segregation of the powders discharging from an Intermediate Bulk Container (IBC) to the tablet press via a vertical chute.

Segregation tests were carried out on trial powder blend materials supplied by GlaxoSmithKline (GSK), using a laboratory-scale air elutriation test facility at The Wolfson Centre. Particle size analysis of the virgin and segregated sub-samples clearly indicated that powder segregation occurred as a result of aerodynamic effects. Subsequent chemical assay results concurred with the particle size results. Flowability testing of the powder blends indicated them to be free-flowing materials; this in addition to the presence of large particle size differentials within the powder blends is the likely cause of the susceptibility to air-induced segregation.

Item Type: Article
Uncontrolled Keywords: air induced segregation, pharmaceutical powders, flow functions
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Faculty / Department / Research Group: Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Related URLs:
Last Modified: 17 Oct 2016 10:03
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/6967

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