Investigations on air induced segregation of pharmaceutical powders and effect of material flow functions
Deng, Tong, Paul, Kirsty A., Bradley, Michael S.A., Immins, Lee, Preston, Chris, Scott, Jerry F. and Welfare, Eloise H. (2010) Investigations on air induced segregation of pharmaceutical powders and effect of material flow functions. Powder Technology, 203 (2). pp. 354-358. ISSN 0032-5910 (doi:10.1016/j.powtec.2010.05.028)Full text not available from this repository.
For the pharmaceutical industry, powder segregation can occur in many processes such as blending and compression solid dose unit operations. Yet it is important that the high quality standards of drug product manufacture are maintained throughout the whole processes. Powder segregation has been identified by the pharmaceutical industry as a potential issue, and in some cases it may cause variability in tablet assay and uniformity throughout a compression run. Early studies suggested for certain Direct Compression (DC) products, the separation of Active Pharmaceutical Ingredient (API) from excipients could arise due to air-induced segregation of the powders discharging from an Intermediate Bulk Container (IBC) to the tablet press via a vertical chute.
Segregation tests were carried out on trial powder blend materials supplied by GlaxoSmithKline (GSK), using a laboratory-scale air elutriation test facility at The Wolfson Centre. Particle size analysis of the virgin and segregated sub-samples clearly indicated that powder segregation occurred as a result of aerodynamic effects. Subsequent chemical assay results concurred with the particle size results. Flowability testing of the powder blends indicated them to be free-flowing materials; this in addition to the presence of large particle size differentials within the powder blends is the likely cause of the susceptibility to air-induced segregation.
|Uncontrolled Keywords:||air induced segregation, pharmaceutical powders, flow functions|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
T Technology > TP Chemical technology
|School / Department / Research Groups:||School of Computing & Mathematical Sciences|
School of Computing & Mathematical Sciences > Centre for Numerical Modelling & Process Analysis
School of Engineering
School of Engineering > Wolfson Centre for Bulk Solids Handling Technology
|Last Modified:||18 Dec 2013 10:37|
Actions (login required)