Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
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Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901
Full text not available from this repository.Official URL: http://dx.doi.org/10.1039/C1MT00017A
Abstract
(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | synthesis, evaluation, metallocene, methylidene-1,3-dihydro-2H-indol-2-ones, kinase inhibitors |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
| School / Department / Research Groups: | School of Science |
| Related URLs: | |
| Last Modified: | 12 Feb 2013 13:14 |
| URI: | http://gala.gre.ac.uk/id/eprint/6903 |
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