Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)Full text not available from this repository.
(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.
|Uncontrolled Keywords:||synthesis, evaluation, metallocene, methylidene-1,3-dihydro-2H-indol-2-ones, kinase inhibitors|
|Subjects:||Q Science > QD Chemistry
R Medicine > R Medicine (General)
|School / Department / Research Groups:||School of Science
Faculty of Engineering & Science > School of Science
|Last Modified:||12 Feb 2013 13:14|
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