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Development and evaluation of Cetirizine HCl taste-masked oral disintegrating tablets

Development and evaluation of Cetirizine HCl taste-masked oral disintegrating tablets

Douroumis, Dionysios, Gryczke, Andreas and Schminke, Silke (2011) Development and evaluation of Cetirizine HCl taste-masked oral disintegrating tablets. AAPS PharmSci Tech, 12 (1). pp. 141-151. ISSN 1530-9932 (Online) (doi:10.1208/s12249-010-9569-7)

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Abstract

The purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio of superdisintegrants such as sodium croscarmellose, crospovidone grades and low substituted hydroxypropyl cellulose (L-HPC). A direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets including porosity, hardness, friability and dissolution profiles were further investigated. The in vitro and in vivo evaluation of the tablet disintegration times showed almost identical rapid disintegration below 10 s at the optimal levels of each superdisintegrant. Finally, the taste and sensory evaluation in human volunteers demonstrated excellence in masking the bitter active and tablet palatability.

Item Type: Article
Uncontrolled Keywords: taste-masking, oral disintegrating tablets, fluidized-bed coating, superdisintegrants
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 11:14
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/6398

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