Skip navigation

Orally disintegrating dosage forms and taste-masking technologies; 2010

Orally disintegrating dosage forms and taste-masking technologies; 2010

Douroumis, Dennis (2011) Orally disintegrating dosage forms and taste-masking technologies; 2010. Expert Opinion on Drug Delivery, 8 (5). pp. 665-675. ISSN 1742-5247 (Print), 1744-7593 (Online) (doi:10.1517/17425247.2011.566553)

Full text not available from this repository.

Abstract

Introduction: In the last decade the development of orally disintegrating tablets (ODTs) and thin-film platforms has grown enormously in the field of pharmaceutical industry. A wide variety of new masking technologies combined with the aforementioned platforms have been developed in order to mask the taste of bitter active substances and achieve patient compliance. The commercial success and viability of such products requires the development of robust formulations with excellent palatability, disintegration times, physicochemical stability and pharmacokinetic profiles.

Areas covered: In this review, emerging taste-masking technologies applied to solid dosage form manufacturing are summarized. The unique features and principles of taste-masking approaches used with ODT platforms are discussed, including the advantages and limitations of each technology. A brief discussion is also included on the taste masking of thin-film technologies, owing to their similar applications and requirements.

Expert opinion: This review elucidates the unique features of current commercially available or highly promising ODT and thin-film technologies, along with taste-masking approaches used in the manufacturing of oral solid dosage forms. A better understanding of these drug delivery approaches will help researchers to select the appropriate platform, or to develop innovative products with improved safety, compliance and clinical value.

Item Type: Article
Uncontrolled Keywords: complexation, drug delivery, microencapsulation, orally disintegrating tables, taste masking
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 22 Nov 2016 16:02
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/6396

Actions (login required)

View Item View Item