Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity
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Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896
Full text not available from this repository.Official URL: http://dx.doi.org/10.1016/j.bmc.2011.01.010
Abstract
A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 lM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | parallel synthesis, microwaves, benzodiazepines, trypanosoma |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
| School / Department / Research Groups: | School of Science School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences |
| Related URLs: | |
| Last Modified: | 13 Apr 2012 17:47 |
| URI: | http://gala.gre.ac.uk/id/eprint/5837 |
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