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Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight: Towards the preparation of hybrids with anticoagulant properties

Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight: Towards the preparation of hybrids with anticoagulant properties

Fatouros, Dimitrios G., Power, Kieron, Kadir, Omar, Dékány, Imre, Yannopoulos, Spyros N., Bouropoulos, Nikolaos, Bakandritsos, Aristides, Antonijevic, Milan D., Zouganelis, George D. and Roldo, Marta (2011) Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight: Towards the preparation of hybrids with anticoagulant properties. Nanoscale, 3 (3). pp. 1218-1224. ISSN 2040-3364 (Print), 2040-3372 (Online) (doi:10.1039/C0NR00952K)

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Abstract

We have previously demonstrated that chitosan derivative N-octyl-O-sulfate chitosan (NOSC), which presents important pharmacological properties, can suspend single walled carbon nanotubes (SWNTs) up to 20 times more effectively than other chitosan derivatives in an aqueous environment. In an attempt to further investigate the impact of different molecular weights of chitosan to the solubilization and anticoagulant properties of these hybrids an array of NOSC derivatives varying their molecular weight (low, medium and high respectively) was synthesised and characterised by means of FT-IR spectroscopy, NMR spectroscopy and thermal gravimetric analysis (TGA). Microwave and nitric acid purified SWNTs, characterised by FT-IR spectroscopy, transmission electron microscopy (TEM) and Raman spectroscopy, were colloidally stabilised by these polymers and their anticoagulant activity was assessed. The results revealed that the low molecular weight NOSC coated SWNTs exhibit the highest activity when 0.5 mg mL−1 NOSC solutions are used, activity which is similar to that of the free polymer. Preliminary studies by exposure of these hybrids to Brine Shrimp (Artemia) cysts revealed no effect on the viability of sub-adult Artemia. Our findings suggest the possibility of tailoring these nanomaterials to bear the required properties for application as biocompatible building blocks for nanodevices including biosensors and biomaterials.

Item Type: Article
Additional Information: [1] First published online: 24 Jan 2011. [2] First published in print: 1 March 2011. [3] Published in Nanoscale, March 01 2011, Issue 3, pp. 1218–1224. [4] Nanoscale is a collaborative venture between RSC Publishing and a leading nanoscience research centre, the National Center for Nanoscience and Technology (NCNST) in Beijing, China.
Uncontrolled Keywords: chitosan derivative, thermogravimetric analysis
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 11:28
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4444

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