Poly(alkyl methacrylate) tooth coatings for dental care: evaluation of the demineralisation-protection benefit using a time-resolved in vitro method
Nielsen, Birthe V., Nevell, Thomas G., Barbu, Eugen, Smith, James R., Rees, Gareth D. and Tsibouklis, John (2011) Poly(alkyl methacrylate) tooth coatings for dental care: evaluation of the demineralisation-protection benefit using a time-resolved in vitro method. Polymers, 3 (1). pp. 314-329. ISSN 2073-4360 (doi:10.3390/polym3010314)
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An in vitro method for the time-resolved quantification of acid-mediated tooth demineralisation has been developed and evaluated against putative non-permanent protective formulations based on a series of poly(alkyl methacrylate)s. Using a thermostatted carousel, dentally relevant substrates consisting of hydroxyapatite discs or sections of bovine teeth have been exposed to aqueous citric acid under controlled conditions, before and after being treated with the polymeric coatings. The dissolution of phosphate was monitored by the determination of 31P by Inductively Coupled Plasma—Mass Spectrometry and by the spectrophotometric phosphovanadomolybdate method. Dose-response plots constructed for both groups of treated substrates have revealed that the coatings significantly reduce erosion rates but are less effective at inhibiting tooth demineralisation than the standard fluoride treatment. The approach has enabled an evaluation of the erosion-protection efficiency of each coating.
|Additional Information:|| First published online: 19 January 2011.  Polymers is an online-only journal, ISSN 2073-4360 (Online).  Paper published in Polymers - Special Issue: Biofunctional Polymers for Medical Applications.  Polymers is an open access journal, with articles published by MDPI online under Creative Commons Attribution License. Copyright: © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).|
|Uncontrolled Keywords:||tooth demineralisation, ICP-MS, phosphovanadomolybdate, poly(alkyl methacrylate), erosion-protection coating|
|Subjects:||Q Science > QD Chemistry|
R Medicine > RK Dentistry
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||07 May 2013 15:54|
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