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Predictive milling of pharmaceutical materials using nanoindentation of single crystals

Predictive milling of pharmaceutical materials using nanoindentation of single crystals

Taylor, L.J., Papadopoulos, D.G., Dunn, P.J., Bentham, A.C., Dawson, N.J., Mitchell, J.C. and Snowden, M.J. (2004) Predictive milling of pharmaceutical materials using nanoindentation of single crystals. Organic Process Research & Development, 8 (4). pp. 674-679. ISSN 1083-6160 (Print), 1520-586X (Online) (doi:10.1021/op0300241)

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Abstract

Five pharmaceutical materials, including two salts and three neutral compounds, have been subjected to nanoindentation analysis on a single-crystal scale. The nanoindentation experiments were used to calculate a brittleness index for each of the five materials. These results were compared to the size reductions that were obtained on a pilot-plant scale mill. A good correlation between single crystal and large pilot-plant scale results was obtained for the range of materials studied.

Item Type: Article
Additional Information: [1] First published online: May 13 2004. [2] Technology Report
Uncontrolled Keywords: nanoindentation, single crystals
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science
Related URLs:
Last Modified: 14 Oct 2016 09:11
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4201

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