Predictive milling of pharmaceutical materials using nanoindentation of single crystals
Taylor, L.J., Papadopoulos, D.G., Dunn, P.J., Bentham, A.C., Dawson, N.J., Mitchell, J.C. and Snowden, M.J. (2004) Predictive milling of pharmaceutical materials using nanoindentation of single crystals. Organic Process Research & Development, 8 (4). pp. 674-679. ISSN 1083-6160 (Print), 1520-586X (Web) (doi:10.1021/op0300241)Full text not available from this repository.
Five pharmaceutical materials, including two salts and three neutral compounds, have been subjected to nanoindentation analysis on a single-crystal scale. The nanoindentation experiments were used to calculate a brittleness index for each of the five materials. These results were compared to the size reductions that were obtained on a pilot-plant scale mill. A good correlation between single crystal and large pilot-plant scale results was obtained for the range of materials studied.
|Additional Information:|| First published online: May 13 2004.  Technology Report|
|Uncontrolled Keywords:||nanoindentation, single crystals|
|Subjects:||Q Science > QD Chemistry|
R Medicine > RS Pharmacy and materia medica
|School / Department / Research Groups:||School of Science|
School of Science > Medway Sciences Research Group
|Last Modified:||23 Nov 2012 14:15|
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