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The use of colloidal microgels for the controlled delivery of proteins and peptides

The use of colloidal microgels for the controlled delivery of proteins and peptides

Cornelius, Victoria J., Snowden, Martin J. and Mitchell, John C. ORCID: 0000-0003-2945-3292 (2006) The use of colloidal microgels for the controlled delivery of proteins and peptides. In: Smart Materials IV (Proceedings Volume). Proceedings of the Society of Photo-Optical Instrumentation Engineers (SPIE), 64130Y (6413). Society of Photo-Optical Instrumentation Engineers (SPIE), Bellingham, Washington USA. ISBN 9780819465214 (doi:10.1117/12.712578)

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Abstract

Colloidal microgels may be used for the absorption and controlled release of confirmationally sensitive molecules such as proteins and peptides. These monodisperse microgels are easily prepared in a single pot reaction from e.g. Nisopropylacrylamide, butyl acrylate and methacrylic acid in the presence of a cross-linking agent and a suitable free radical initiator. The resultant materials display dramatic conformational changes in aqueous dispersion in response to changes in e.g. environmental pH. Colloidal microgels are capable of absorbing a range of different proteins and peptides at one pH, affording them protection by changing the conformation of the microgel following a pH change. A further change in environmental pH will allow the microgel to adopt a more extended confirmation and therefore allow the release of the encapsulated material. In the case of e.g. insulin this would offer the possibility of an oral delivery route. At the pH of stomach the microgel adopts a compact conformation, "protecting" the protein from denaturation. As the pH increases passing into the GI tract, the microgel changes its conformation to a more expanded form and thereby allows the protein to be released. Colloidal microgels offer an opportunity for the controlled release of conformationally sensitive protein and peptide molecules via an oral route.

Item Type: Conference Proceedings
Title of Proceedings: Smart Materials IV (Proceedings Volume)
Additional Information: [1] First published online: 22 December 2006. [2] SPIE is the The International Society for Optical Engineering. [3] This paper was presented at the SPIE International Symposium on Smart Materials, Nano-and Micro-Smart System, Adelaide University, Adelaide, AUSTRALIA, 11-13 December 2006. [4] SPIE Proceedings, Volume 6413.
Uncontrolled Keywords: colloidal microgels, absorption, dispersion, molecules, mouth, stomach
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4155

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